Endocrine Abstracts

Introduction: Multiple endocrine neoplasia type 2A (MEN2A) is a rare genetic condition characterized by medullary thyroid cancer (MTC), often accompanied by primary hyperparathyroidism (PHPT) in 20% to 30% of cases which is usually detected while investigating other issues and is not commonly the initial indicator of the condition. This study aims to describe the specific features of primary hyperparathyroidism (PHPT) in MEN2A, providing insights into its distinct characterist...

Introduction: Primary hyperparathyroidism is frequently accompanied by low vitamin D levels. This study aims to assess the vitamin D status of patients diagnosed with primary hyperparathyroidism, with a focus on determining the prevalence of insufficient and deficient 25(OH) D levels in this patient population.Patients and Methods: Conducted as a retrospective study over a 7-year period (2015-2022), our research was carried out at the endocrinology-diabe...

Introduction: Hungry Bone Syndrome (HBS) is characterized by a profound and persistent state of hypocalcemia, typically observed following parathyroidectomy or thyroidectomy. This syndrome manifests in the postoperative period, and its occurrence is associated with extended exposure to elevated levels of parathyroid hormone (PTH) or thyrotoxicosis. This prolonged exposure results in heightened bone turnover rates, marked by a net loss of bone minerals through resorption. We re...

Introduction: Primary hyperparathyroidism (PPH) may be complicated by pancreatitis. The association of primary hyperparathyroidism with pancreatitis is rare, We report the case of three patients presenting with hyperparathyroidism revealed by acute pancreatitis.Observation: A 78-year-old female patient with no previous history of pancreatitis presented to the emergency department with abdominal pain and bilious vomiting. An abdominal CT scan was ordered,...

Theassociation of primary hyperparathyroidism with autoimmune diseases is described very rarely in the literature so far. There are only few cases of immune-mediated hyperparathyroidism, associated with anti-calcium- sensing receptor autoantibodies, Recent epidemiological studies have shown that coeliac disease is more common than previously thought, with prevalence approaching 1%.Observation : A 47-year-old woman was diagnosed as having coeliac disease ...

Introduction: Moringa oleifera (MO) (also known as ‘drumstick’) is a tree belonging to the family Moringaceae, genus Moringa, originally native from the Himalayans but currently cultivated in many tropical and subtropical regions around the world. It has been used as a food source and for traditional medicine purposes due to possible antihyperglycemic, antioxidant, anti-inflammatory, and lipid regulating properties, and have been reported earlier by different scienti...

Introduction and importance: Ovarian Sertoli-Leydig cell tumors (SLCT) are rare sex cord-stromal tumors, representing less than 0.5% of all ovarian malignancies. Typically diagnosed at a young age, with 75% of patients having an average onset age of less than 30, these tumors often present a management challenge due to their early detection in young women. The primary dilemma lies in striking the right balance between implementing an effective treatment to prevent recurrences ...

Introduction and importance: Insulinoma is a rare pancreatic neuroendocrine tumor characterized by hypersecretion of insulin, leading to neuroglycopenia symptoms and heightened sympathoadrenal activity. Incidence ranges from 1 to 4 cases per million inhabitants annually, with a predilection for females in their fourth or fifth decade. Despite its rarity, underdiagnosis is suggested by autopsy studies, revealing higher prevalence. Clinical manifestations often mimic other condi...

Introduction: Arterial hypertension of endocrine origin remains a rare and curable cause of hypertension. The association of hypertension and hypokalemia should always prompt us to consider cushing’s disease.Case Report: A 39-year-old female patient, followed for 9 years for hypertension on dual therapy. Clinical examination was unremarkable, in whom the diagnosis of ACTH-dependent cushing’s syndrome was made on the basis of clinical and biolog...

Introduction: Prolactin adenomas are the most common pituitary tumors. The aim of treatment is to achieve normal prolactin levels in order to reduce tumor mass and restore the gonadotropic axis. Dopaminergic agonists, including cabergoline, are the standard treatment. But some adenomas can be resistant to this treatment and behave like aggressive tumors. We report the case of a macroprolactinoma resistant to cabergoline.Observation: 50-year-old female pa...